Thebrain 8 vs thebrain 9
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For the quantification of this otherwise abstract construct, cognitive resilience can be measured directly using an established latent variable modeling approach. Conversely, low cognitive resilience is a condition in which an individual has cognitive performance that is similar or worse than expected. Cognitive resilience is a condition in which an individual has observed cognitive performance better than expected given their brain’s structure. 6, 8 The core premise is that cognitive resilience is the difference between an individual’s expected and actual cognitive performance, given their underlying brain structure and level of vulnerability to neuropathological changes. Cognitive resilience is a theoretical concept that attempts to explain this general capacity to remain cognitively unimpaired despite age- or ADRD-related pathological changes, 3 - 6 so clarifying these pathways has important implications for dementia prevention initiatives.Īlthough broad consensus of operational definitions and research guidelines for cognitive resilience are in development, 7 a working Alzheimer Association research framework proposes that cognitive resilience–enhancing factors-by definition-modify the association between physical brain changes attributable to age or disease and cognitive performance. Studies 1, 2 indicate that not all older adults with substantial neuropathology attributable to Alzheimer disease and related disorders (ADRD) develop dementia. A refined understanding of social support mechanisms has the potential to inform strategies to reduce ADRD risk and enhance cognitive resilience. Other forms of social support were not significant modifiers (advice: β = −0.04 P = .40 for interaction love-affection: β = −0.07, P = .28 for interaction emotional support: β = −0.02, P = .73 for interaction and sufficient contact: β = −0.08 P = .11 for interaction).Ĭonclusions and Relevance The results of this cross-sectional cohort study suggest that social support in the form of supportive listening is associated with greater cognitive resilience, independently modifying the association between lower total cerebral volume and poorer cognitive function that would otherwise indicate increased ADRD vulnerability at the preclinical stage. Overall findings persisted after adjustment for potential confounders. High listener availability was associated with greater cognitive resilience (β = 0.08, P < .001) compared with low listener availability (β = 0.20, P = .002). Results The study included 2171 adults (164 in the original cohort and 2007 in the offspring cohort mean age, 63 years 1183 female). Cognitive resilience was defined as the modification of total cerebral volume’s association with cognition, such that smaller β estimates (presented in SD units) indicate greater cognitive resilience (ie, better cognitive performance than estimated by lower total cerebral volume). Main Outcomes and Measures The primary outcome was a global measure of cognitive function. Data were analyzed from May 22, 2017, to June 1, 2021.Įxposures Total cerebral volume and, as a modifying exposure variable, self-reported availability of 5 types of social support measured by the Berkman-Syme Social Network Index. Data from this large, population-based, longitudinal cohort were collected from June 6, 1997, to Decem(original cohort), and from September 11, 1998, to Octo(offspring cohort). Objective To examine the association of individual forms of social support with a global neuroanatomical measure of early ADRD vulnerability and cognition.ĭesign, Setting, and Participants This retrospective cross-sectional analysis used prospectively collected data from Framingham Study participants without dementia, stroke, or other neurological conditions who underwent brain magnetic resonance imaging and neuropsychological testing at the same visit. Studies suggest that supportive social networks reduce Alzheimer disease and related disorder (ADRD) risk by enhancing cognitive resilience, but data on specific social support mechanisms are sparse. Importance Cognitive resilience refers to the general capacity of cognitive processes to be less susceptible to differences in brain structure from age- and disease-related changes. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.